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ABSTRACT:
SUBMITTER: Ferrer-Casal M
PROVIDER: S-EPMC3902031 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Ferrer-Casal Mariana M Li Catherine C Galizzi Melina M Stortz Carlos A CA Szajnman Sergio H SH Docampo Roberto R Moreno Silvia N J SN Rodriguez Juan B JB
Bioorganic & medicinal chemistry 20131113 1
As part of our project pointed at the search of new antiparasitic agents against American trypanosomiasis (Chagas disease) and toxoplasmosis a series of 2-alkylaminoethyl-1-hydroxy-1,1-bisphosphonic acids has been designed, synthesized and biologically evaluated against the etiologic agents of these parasitic diseases, Trypanosoma cruzi and Toxoplasma gondii, respectively, and also towards their target enzymes, T. cruzi and T. gondii farnesyl pyrophosphate synthase (FPPS), respectively. Surprisi ...[more]