Effects of smoking, gender and occupational exposure on the risk of severe pulmonary fibrosis: a population-based case-control study.

ABSTRACT:

Objectives

To estimate the effects of smoking, gender and occupational exposure on the risk of developing severe pulmonary fibrosis (PF), including dose-response and interaction effects.

Methods

National case-control study of 171 patients (cases) who had started a long-term oxygen therapy for PF in Sweden between February 1997 and April 2000, and 719 random control participants from the general population. Of these cases, 137 had probable idiopathic PF (IPF). The ORs for smoking, gender and occupational exposure were estimated using Mantel-Haenszel analysis and conditional logistic regression, controlling for age and year of diagnosis.

Results

The adverse effect of smoking was amplified by male gender and occupational exposure, OR 4.6 (95% CI 2.1 to 10.3) for PF, and

SUBMITTER: Ekstrom M 

PROVIDER: S-EPMC3902328 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature