Dataset Information

Long-term mortality after community-acquired sepsis: a longitudinal population-based cohort study.

ABSTRACT:

Objective

Prior studies have concentrated on the acute short-term outcomes of sepsis, with little focus on its long-term consequences. The objective of this study was to characterise long-term mortality following a sepsis event.

Design

Population-based data from the 30 239 community-dwelling individuals in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort.

Setting usa participants

Community-dwelling adults ?45 years of age. Sepsis was defined as hospitalisation or emergency department treatment for a serious infection with the presence of ?2 systemic inflammatory response syndrome criteria.

Outcomes

6-year all-cause mortality. The analysis utilised a time-varying Cox model adjusted for participant's age, demographic factors, health behaviours and chronic medical conditions.

Results

The participants were observed for a median of 6.1 years (IQR 4.5-7.1). During this period, 975 individuals experienced a sepsis event. Sepsis hospital mortality was 8.9%. One-year, 2-year and 5-year all-cause mortality among individuals with sepsis were 23%, 28.8% and 43.8%, respectively, compared with death rates of 1%, 2.6% and 8.3% among those who never developed sepsis. On multivariable analysis, the association of sepsis with increased all-cause mortality persisted for up to 5 years, after adjustment for confounders; year 0.00-1.00, adjusted HR (aHR) 13.07 (95% CI 10.63 to 16.06); year 1.01-2.00 aHR 2.64 (1.85 to 3.77); year 2.01-3.00 aHR 2.18 (1.43 to 3.33); year 3.01-4.00 aHR 1.97 (1.19 to 3.25); year 4.01-5.00 aHR 2.08 (1.14 to 3.79); year 5.01+ aHR 1.41 (0.67 to 2.98).

Conclusions

Individuals with sepsis exhibited increased rates of death for up to 5 years after the illness event, even after accounting for comorbidities. Sepsis is independently associated with increased risk of mortality well after hospital treatment.

SUBMITTER: Wang HE

PROVIDER: S-EPMC3902401 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Publications

Long-term mortality after community-acquired sepsis: a longitudinal population-based cohort study.

Wang Henry E HE Szychowski Jeff M JM Griffin Russell R Safford Monika M MM Shapiro Nathan I NI Howard George G

BMJ open 20140117 1

<h4>Objective</h4>Prior studies have concentrated on the acute short-term outcomes of sepsis, with little focus on its long-term consequences. The objective of this study was to characterise long-term mortality following a sepsis event.<h4>Design</h4>Population-based data from the 30 239 community-dwelling individuals in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort.<h4>Setting usa participants</h4>Community-dwelling adults ≥45 years of age. Sepsis was defined as h ...[more]

PMID: 24441058

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Dataset Information

Long-term mortality after community-acquired sepsis: a longitudinal population-based cohort study.

Objective

Design

Setting usa participants

Outcomes

Results

Conclusions

Publications

Long-term mortality after community-acquired sepsis: a longitudinal population-based cohort study.

Similar Datasets

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