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How does carbon nanoring deform to spiral induced by carbon nanotube?

ABSTRACT: Molecular dynamics (MD) simulations have been performed on the interaction between carbon nanoring (CNR) and single-wall carbon nanotube (SWCNT). The results show that, the CNR can spontaneously insert into the hollow interior of the SWCNTs to form a DNA-like double-helix, or collapse to a linked double graphitic nanoribbon and wrap in a helical manner around a tube. Further analyses of energy components show that this unique phenomenon is the result of the Van der Waals interaction. The spiral configuration of the CNR takes the least amount of energy and achieves the maximum occupancy. The sizes of CNR and SWCNT should meet the required conditions to guarantee the spiral form in the insertion and wrapping processes. Two CNRs can also be encapsulated in the SWCNT to form a helix at the same time. Furthermore, we also studied the encapsulation process of CNRs modified with -OH and -H functional groups.

SUBMITTER: Chen W

PROVIDER: S-EPMC3902510 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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How does carbon nanoring deform to spiral induced by carbon nanotube?

Chen Wei W Li Hui H

Scientific reports 20140127

Molecular dynamics (MD) simulations have been performed on the interaction between carbon nanoring (CNR) and single-wall carbon nanotube (SWCNT). The results show that, the CNR can spontaneously insert into the hollow interior of the SWCNTs to form a DNA-like double-helix, or collapse to a linked double graphitic nanoribbon and wrap in a helical manner around a tube. Further analyses of energy components show that this unique phenomenon is the result of the Van der Waals interaction. The spiral ...[more]

PMID: 24463737

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Project description:Carbon nanotubes were among the earliest products of nanotechnology and have many potential applications in medicine, electronics, and manufacturing. The low density, small size, and biological persistence of carbon nanotubes create challenges for exposure control and monitoring and make respiratory exposures to workers likely. We have previously shown mitotic spindle aberrations in cultured primary and immortalized human airway epithelial cells exposed to 24, 48 and 96 ?g/cm(2) single-walled carbon nanotubes (SWCNT). To investigate mitotic spindle aberrations at concentrations anticipated in exposed workers, primary and immortalized human airway epithelial cells were exposed to SWCNT for 24-72 h at doses equivalent to 20 weeks of exposure at the Permissible Exposure Limit for particulates not otherwise regulated. We have now demonstrated fragmented centrosomes, disrupted mitotic spindles and aneuploid chromosome number at those doses. The data further demonstrated multipolar mitotic spindles comprised 95% of the disrupted mitoses. The increased multipolar mitotic spindles were associated with an increased number of cells in the G2 phase of mitosis, indicating a mitotic checkpoint response. Nanotubes were observed in association with mitotic spindle microtubules, the centrosomes and condensed chromatin in cells exposed to 0.024, 0.24, 2.4 and 24 ?g/cm(2) SWCNT. Three-dimensional reconstructions showed carbon nanotubes within the centrosome structure. The lower doses did not cause cytotoxicity or reduction in colony formation after 24h; however, after three days, significant cytotoxicity was observed in the SWCNT-exposed cells. Colony formation assays showed an increased proliferation seven days after exposure. Our results show significant disruption of the mitotic spindle by SWCNT at occupationally relevant doses. The increased proliferation that was observed in carbon nanotube-exposed cells indicates a greater potential to pass the genetic damage to daughter cells. Disruption of the centrosome is common in many solid tumors including lung cancer. The resulting aneuploidy is an early event in the progression of many cancers, suggesting that it may play a role in both tumorigenesis and tumor progression. These results suggest caution should be used in the handling and processing of carbon nanotubes.

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How does carbon nanoring deform to spiral induced by carbon nanotube?

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How does carbon nanoring deform to spiral induced by carbon nanotube?

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