Ontology highlight
ABSTRACT:
SUBMITTER: Singh S
PROVIDER: S-EPMC3902635 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Singh Shweta S Plaks Joseph G JG Homa Nicholas J NJ Amrich Christopher G CG Héroux Annie A Hatfull Graham F GF VanDemark Andrew P AP
Journal of molecular biology 20131007 2
The recombination directionality factor, Xis, is a DNA bending protein that determines the outcome of integrase-mediated site-specific recombination by redesign of higher-order protein-DNA architectures. Although the attachment site DNA of mycobacteriophage Pukovnik is likely to contain four sites for Xis binding, Xis crystals contain five subunits in the asymmetric unit, four of which align into a Xis filament and a fifth that is generated by an unusual domain swap. Extensive intersubunit conta ...[more]