Ontology highlight
ABSTRACT:
SUBMITTER: Poeschla EM
PROVIDER: S-EPMC3902792 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Cellular and molecular life sciences : CMLS 20080501 9
HIV integrates a DNA copy of its genome into a host cell chromosome in each replication cycle. The essential DNA cleaving and joining chemistry of integration is known, but there is less understanding of the process as it occurs in a cell, where two complex and dynamic macromolecular entities are joined: the viral pre-integration complex and chromatin. Among implicated cellular factors, much recent attention has coalesced around LEDGF/p75, a nuclear protein that may act as a chromatin docking fa ...[more]