Ontology highlight
ABSTRACT:
SUBMITTER: Ramos I
PROVIDER: S-EPMC3902905 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Ramos Isbaal I Fernández-Rivero Noelia N Arranz Rocío R Aloria Kerman K Finn Ron R Arizmendi Jesús M JM Ausió Juan J Valpuesta José María JM Muga Arturo A Prado Adelina A
Nucleic acids research 20131010 2
The role of Nucleoplasmin (NP) as a H2A-H2B histone chaperone has been extensively characterized. To understand its putative interaction with other histone ligands, we have characterized its ability to bind H3-H4 and histone octamers. We find that the chaperone forms distinct complexes with histones, which differ in the number of molecules that build the assembly and in their spatial distribution. When complexed with H3-H4 tetramers or histone octamers, two NP pentamers form an ellipsoidal parti ...[more]