Ontology highlight
ABSTRACT:
SUBMITTER: Zhao W
PROVIDER: S-EPMC3902922 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Zhao Weixing W Saro Dorina D Hammel Michal M Kwon Youngho Y Xu Yuanyuan Y Rambo Robert P RP Williams Gareth J GJ Chi Peter P Lu Lucy L Pezza Roberto J RJ Camerini-Otero R Daniel RD Tainer John A JA Wang Hong-Wei HW Sung Patrick P
Nucleic acids research 20131022 2
The Hop2-Mnd1 complex functions with the DMC1 recombinase in meiotic recombination. Hop2-Mnd1 stabilizes the DMC1-single-stranded DNA (ssDNA) filament and promotes the capture of the double-stranded DNA partner by the recombinase filament to assemble the synaptic complex. Herein, we define the action mechanism of Hop2-Mnd1 in DMC1-mediated recombination. Small angle X-ray scattering analysis and electron microscopy reveal that the heterodimeric Hop2-Mnd1 is a V-shaped molecule. We show that the ...[more]