Ontology highlight
ABSTRACT:
SUBMITTER: Jiang P
PROVIDER: S-EPMC3903179 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Jiang Peng P Chen Chen C Wang Ruimin R Chechneva Olga V OV Chung Seung-Hyuk SH Rao Mahendra S MS Pleasure David E DE Liu Ying Y Zhang Quanguang Q Deng Wenbin W
Nature communications 20130101
Human pluripotent stem cells (hPSCs) have been differentiated to astroglia, but the utilization of hPSC-derived astroglia as cell therapy for neurological diseases has not been well studied. Astroglia are heterogeneous, and not all astroglia are equivalent in promoting neural repair. A prerequisite for cell therapy is to derive defined cell populations with superior therapeutic effects. Here we use an Olig2-GFP human embryonic stem cell (hESC) reporter to demonstrate that hESC-derived Olig2(+) p ...[more]