TRAIL-coated leukocytes that kill cancer cells in the circulation.
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ABSTRACT:
SUBMITTER: Mitchell MJ
PROVIDER: S-EPMC3903223 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
TRAIL-coated leukocytes that kill cancer cells in the circulation.
Mitchell Michael J MJ Wayne Elizabeth E Rana Kuldeepsinh K Schaffer Chris B CB King Michael R MR
Proceedings of the National Academy of Sciences of the United States of America 20140106 3
Metastasis through the bloodstream contributes to poor prognosis in many types of cancer. Mounting evidence implicates selectin-based adhesive interactions between cancer cells and the blood vessel wall as facilitating this process, in a manner similar to leukocyte trafficking during inflammation. Here, we describe a unique approach to target and kill colon and prostate cancer cells in the blood that causes circulating leukocytes to present the cancer-specific TNF-related apoptosis inducing liga ...[more]
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