Ontology highlight
ABSTRACT:
SUBMITTER: Knudsen NP
PROVIDER: S-EPMC3903227 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Knudsen Niels Peter H NP Nørskov-Lauritsen Sara S Dolganov Gregory M GM Schoolnik Gary K GK Lindenstrøm Thomas T Andersen Peter P Agger Else Marie EM Aagaard Claus C
Proceedings of the National Academy of Sciences of the United States of America 20140106 3
A central goal in vaccine research is the identification of relevant antigens. The Mycobacterium tuberculosis chromosome encodes 23 early secretory antigenic target (ESAT-6) family members that mostly are localized as gene pairs. In proximity to five of the gene pairs are ESX secretion systems involved in the secretion of the ESAT-6 family proteins. Here, we performed a detailed and systematic investigation of the vaccine potential of five possible Esx dimer substrates, one for each of the five ...[more]