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Clinical Cerenkov luminescence imaging of (18)F-FDG.


ABSTRACT: The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic (18)F-FDG scans to detect nodal disease.Patients undergoing routine (18)F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal (18)F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera.The camera demonstrated linear correlation between activity and counts into the low nanocurie range using (18)F-FDG. Imaging of patients revealed the presence of (18)F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established.CL imaging with diagnostic doses of (18)F-FDG is feasible and can aid in detecting disease in the clinical setting.

SUBMITTER: Thorek DL 

PROVIDER: S-EPMC3903390 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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Clinical Cerenkov luminescence imaging of (18)F-FDG.

Thorek Daniel L J DL   Riedl Christopher C CC   Grimm Jan J  

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20130927 1


<h4>Unlabelled</h4>The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic (18)F-FDG scans to detect nodal disease.<h4>Methods</h4>Patients undergoing routine (18)F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal (18)F-FDG uptake were acquired using a cooled, intensified charge-cou  ...[more]

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