Increasing newly diagnosed rate and changing risk factors of HCV in Yanbian Prefecture, a high endemic area in China.

ABSTRACT:

Background

The newly diagnosed rate of HCV infection is increasing in China. However, the risk factors have not been fully identified. Here, a survey was performed in Yanbian Prefecture, a high-endemic area in China.

Methods

We identified newly diagnosed HCV infection in 2007-2011, using the local National Disease Supervision Information Management System from the Chinese Center for Disease Control and Prevention. We determined the risk factors using a case-control survey by questionnaire.

Results

Yanbian Prefecture had a rapid increase in the yearly newly diagnosed rate of HCV infection from 32.6 to 72.1/100.000 from the year 2007 to 2011. People aged 50-64 years had a high HCV infection of 43.4%, but only 0.3% of cases were reported in those aged less than 20 years. Cosmetic treatment, family history, blood transfusion, and dental treatment were independent risk factors for HCV infection. Unexpectedly, cosmetic treatments [odd ratio (OR)?=?5.15, 95% confidence interval (CI)?=?2.31-11.48, P?=?0.00] and family history (OR?=?4.68, 95% CI?=?2.67-8.75, P?=?0.00) showed a higher risk than the conventional risk factors of blood transfusion (OR?=?4.49, 95% CI?=?1.95-10.37, P?=?0.001) and dental treatment (OR?=?2.98, 95% CI?=?1.42-6.25, P?=?0.00). To further analyze the intrafamilial transmission, we found that spouses of HCV patients had an increased risk for acquiring HCV (OR?=?5.75, 95% CI: 1.94-17.07), without significant association between either HCV RNA viral load (P?=?0.29) or genotype (P?=?0.43).

Conclusions

HCV infection was increased in Yanbian Prefecture. Cosmetic treatment was a higher risk factor than medical procedure. HCV infection had a clear family clustering phenomenon, especially between spouses.

SUBMITTER: Piao HX 

PROVIDER: S-EPMC3903515 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature