Ontology highlight
ABSTRACT:
SUBMITTER: Steffen JD
PROVIDER: S-EPMC3903668 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Steffen Jamin D JD Tholey Renee M RM Langelier Marie-France MF Planck Jamie L JL Schiewer Matthew J MJ Lal Shruti S Bildzukewicz Nikolai A NA Yeo Charles J CJ Knudsen Karen E KE Brody Jonathan R JR Pascal John M JM
Cancer research 20131104 1
PARP-1 is a nuclear protein that has important roles in maintenance of genomic integrity. During genotoxic stress, PARP-1 recruits to sites of DNA damage where PARP-1 domain architecture initiates catalytic activation and subsequent poly(ADP-ribose)-dependent DNA repair. PARP-1 inhibition is a promising new way to selectively target cancers harboring DNA repair deficiencies. However, current inhibitors target other PARPs, raising important questions about long-term off-target effects. Here, we p ...[more]