Ontology highlight
ABSTRACT:
SUBMITTER: Peng WT
PROVIDER: S-EPMC390369 | biostudies-literature | 2004
REPOSITORIES: biostudies-literature
Peng Wen-Tao WT Krogan Nevan J NJ Richards Dawn P DP Greenblatt Jack F JF Hughes Timothy R TR
Nucleic acids research 20040331 6
We report that Esf1p (Ydr365cp), an essential, evolutionarily conserved nucleolar protein, is required for the biogenesis of 18S rRNA in Saccharomyces cerevisiae. Depletion of Esf1p resulted in delayed processing of 35S precursor and a striking loss of 18S rRNA. Esf1p physically associated with ribosomal proteins and proteins involved in 18S rRNA biogenesis. Consistent with its role in 18S rRNA biogenesis, Esf1p also physically associated with U3 and U14 snoRNAs, but did not appear to be a core ...[more]