Ontology highlight
ABSTRACT:
SUBMITTER: Vasiljevik T
PROVIDER: S-EPMC3904296 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20130522 11
Attenuation of increased endocannabinoid signaling with a CB1R neutral antagonist might offer a new therapeutic direction for treatment of alcohol abuse. We have recently reported that a monohydroxylated metabolite of the synthetic aminoalkylindole cannabinoid JHW-073 (3) exhibits neutral antagonist activity at CB1Rs and thus may serve as a promising lead for the development of novel alcohol abuse therapies. In the current study, we show that systematic modification of an aminoalkylindole scaffo ...[more]