Ontology highlight
ABSTRACT:
SUBMITTER: Goyal J
PROVIDER: S-EPMC3904375 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Goyal Jatinder J Antonarakis Emmanuel S ES
Clinical medicine insights. Urology 20130701 7
Treatment of castration-resistant prostate cancer remains an area of unmet medical need. Evidence suggests that this entity continues to be driven by androgens and androgen receptor (AR) signaling. Abiraterone acetate, a pregnenolone derivative, is an oral selective and irreversible inhibitor of the key steroidogenic enzyme CYP17. It possesses dual 17-α hydroxylase and C17,20-lyase blocking activity, the result of which is decreased gonadal and extra-gonadal androgen synthesis. Abiraterone was f ...[more]