Ontology highlight
ABSTRACT:
SUBMITTER: Deng L
PROVIDER: S-EPMC3904601 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Deng Liufu L Liang Hua H Burnette Byron B Beckett Michael M Darga Thomas T Weichselbaum Ralph R RR Fu Yang-Xin YX
The Journal of clinical investigation 20140102 2
High-dose ionizing irradiation (IR) results in direct tumor cell death and augments tumor-specific immunity, which enhances tumor control both locally and distantly. Unfortunately, local relapses often occur following IR treatment, indicating that IR-induced responses are inadequate to maintain antitumor immunity. Therapeutic blockade of the T cell negative regulator programmed death-ligand 1 (PD-L1, also called B7-H1) can enhance T cell effector function when PD-L1 is expressed in chronically i ...[more]