Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC3904608 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Li Wei W Li Qingle Q Jiao Yang Y Qin Lingfeng L Ali Rahmat R Zhou Jing J Ferruzzi Jacopo J Kim Richard W RW Geirsson Arnar A Dietz Harry C HC Offermanns Stefan S Humphrey Jay D JD Tellides George G
The Journal of clinical investigation 20140109 2
TGF-β is essential for vascular development; however, excess TGF-β signaling promotes thoracic aortic aneurysm and dissection in multiple disorders, including Marfan syndrome. Since the pathology of TGF-β overactivity manifests primarily within the arterial media, it is widely assumed that suppression of TGF-β signaling in vascular smooth muscle cells will ameliorate aortic disease. We tested this hypothesis by conditional inactivation of Tgfbr2, which encodes the TGF-β type II receptor, in smoo ...[more]