Targeting oxidative stress in embryonal rhabdomyosarcoma.
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ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC3904731 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
Targeting oxidative stress in embryonal rhabdomyosarcoma.
Chen Xiang X Stewart Elizabeth E Shelat Anang A AA Qu Chunxu C Bahrami Armita A Hatley Mark M Wu Gang G Bradley Cori C McEvoy Justina J Pappo Alberto A Spunt Sheri S Valentine Marcus B MB Valentine Virginia V Krafcik Fred F Lang Walter H WH Wierdl Monika M Tsurkan Lyudmila L Tolleman Viktor V Federico Sara M SM Morton Chris C Lu Charles C Ding Li L Easton John J Rusch Michael M Nagahawatte Panduka P Wang Jianmin J Parker Matthew M Wei Lei L Hedlund Erin E Finkelstein David D Edmonson Michael M Shurtleff Sheila S Boggs Kristy K Mulder Heather H Yergeau Donald D Skapek Steve S Hawkins Douglas S DS Ramirez Nilsa N Potter Philip M PM Sandoval John A JA Davidoff Andrew M AM Mardis Elaine R ER Wilson Richard K RK Zhang Jinghui J Downing James R JR Dyer Michael A MA
Cancer cell 20131201 6
Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic subtypes, embryonal and alveolar, each with distinct clinical, molecular, and genetic features. Genomic analysis shows that embryonal tumors have more structural and copy number variations than alveolar tumors. Mutations in the RAS/NF1 pathway are significantly associated with intermediate- and high-risk embryonal rhabdomyosarcomas (ERMS). In con ...[more]
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