Ontology highlight
ABSTRACT:
SUBMITTER: Mechaly AE
PROVIDER: S-EPMC3904827 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Mechaly Ariel E AE Sassoon Nathalie N Betton Jean-Michel JM Alzari Pedro M PM
PLoS biology 20140128 1
Histidine kinases (HKs) are dimeric receptors that participate in most adaptive responses to environmental changes in prokaryotes. Although it is well established that stimulus perception triggers autophosphorylation in many HKs, little is known on how the input signal propagates through the HAMP domain to control the transient interaction between the histidine-containing and ATP-binding domains during the catalytic reaction. Here we report crystal structures of the full cytoplasmic region of Cp ...[more]