Loss of connectivity in cancer co-expression networks.
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ABSTRACT:
SUBMITTER: Anglani R
PROVIDER: S-EPMC3904972 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Loss of connectivity in cancer co-expression networks.
Anglani Roberto R Creanza Teresa M TM Liuzzi Vania C VC Piepoli Ada A Panza Anna A Andriulli Angelo A Ancona Nicola N
PloS one 20140128 1
Differential gene expression profiling studies have lead to the identification of several disease biomarkers. However, the oncogenic alterations in coding regions can modify the gene functions without affecting their own expression profiles. Moreover, post-translational modifications can modify the activity of the coded protein without altering the expression levels of the coding gene, but eliciting variations to the expression levels of the regulated genes. These considerations motivate the stu ...[more]
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