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Lipoprotein lipase gene HindIII polymorphism and risk of myocardial infarction in South Indian population.

ABSTRACT: INTRODUCTION: Studies have reported an association between lipoprotein lipase (LPL) gene and myocardial infarction in some populations. Therefore, the present study aimed to investigate the association of the HindIII polymorphism of the (LPL) gene with myocardial infarction and to explore its potential role in susceptibility in a South Indian population. SUBJECTS AND METHODS: We included a total of 412 subjects (202 myocardial infarction patients and 210 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the LPL gene HindIII polymorphism was determined by polymerase chain reaction. RESULTS: Comparison of the lipid profiles between patients and controls showed that patients had statistically high significant values (p = 0.0001). The H(+) H(+) genotype of the LPL gene is associated with myocardial infarction. H(+) H(+) vs. H(-) H(-) was ?2 = 19.4, OR 3.1, CI 95% 1.8-5.2, p < 0.0001. CONCLUSION: Our study strongly suggests that the LPL gene HindIII Hþ Hþ genotype is an independent risk factor for first MI.

SUBMITTER: Tanguturi PR

PROVIDER: S-EPMC3905261 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Lipoprotein lipase gene HindIII polymorphism and risk of myocardial infarction in South Indian population.

Tanguturi Parthasaradhi Reddy PR Pullareddy Bhoomireddy B Rama Krishna B S BS Murthy Dwarkanath K DK

Indian heart journal 20131113 6

<h4>Introduction</h4>Studies have reported an association between lipoprotein lipase (LPL) gene and myocardial infarction in some populations. Therefore, the present study aimed to investigate the association of the HindIII polymorphism of the (LPL) gene with myocardial infarction and to explore its potential role in susceptibility in a South Indian population.<h4>Subjects and methods</h4>We included a total of 412 subjects (202 myocardial infarction patients and 210 age- and sex-matched control ...[more]

PMID: 24407533

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Project description:BACKGROUND:Single nucleotide polymorphisms (SNPs) in lipoprotein lipase gene (LPL) have been shown to influence metabolism related to lipid phenotypes. Dietary factors have been shown to modify the association between LPL SNPs and lipids; however, to date, there are no studies in South Asians. Hence, we tested for the association of four common LPL SNPs with plasma lipids and examined the interactions between the SNPs and dietary factors on lipids in 1,845 Asian Indians. METHODS:The analysis was performed in 788 Type 2 diabetes cases and 1,057 controls randomly chosen from the cross-sectional Chennai Urban Rural Epidemiological Study. Serum triacylglycerol (TAG), serum total cholesterol, and high-density lipoprotein cholesterol (HDL-C) were measured using a Hitachi-912 autoanalyzer (Roche Diagnostics GmbH, Mannheim, Germany). Dietary intake was assessed using a semi-quantitative food frequency questionnaire. The SNPs (rs1121923, rs328, rs4922115 and rs285) were genotyped by polymerase chain reaction followed by restriction enzyme digestion and 20% of samples were sequenced to validate the genotypes obtained. Statistical Package for Social Sciences for Windows version 22.0 (SPSS, Chicago, IL) was used for statistical analysis. RESULTS:After correction for multiple testing and adjusting for potential confounders, SNPs rs328 and rs285 showed association with HDL-C (P?=?0.0004) and serum TAG (P?=?1×10-5), respectively. The interaction between SNP rs1121923 and fat intake (energy %) on HDL-C (P?=?0.003) was also significant, where, among those who consumed a high fat diet (28.4?±?2.5%), the T allele carriers (TT?+?XT) had significantly higher HDL-C concentrations (P?=?0.0002) and 30% reduced risk of low HDL-C levels compared to the CC homozygotes. None of the interactions on other lipid traits were statistically significant. CONCLUSION:Our findings suggest that individuals carrying T allele of the SNP rs1121923 have increased HDL-C levels when consuming a high fat diet compared to CC homozygotes. Our finding warrants confirmation in prospective studies and randomized controlled trials.

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Lipoprotein lipase gene HindIII polymorphism and risk of myocardial infarction in South Indian population.

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Lipoprotein lipase gene HindIII polymorphism and risk of myocardial infarction in South Indian population.

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