Ontology highlight
ABSTRACT:
SUBMITTER: Isham CR
PROVIDER: S-EPMC3905331 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Isham Crescent R CR Bossou Ayoko R AR Negron Vivian V Fisher Kelly E KE Kumar Rakesh R Marlow Laura L Lingle Wilma L WL Smallridge Robert C RC Sherman Eric J EJ Suman Vera J VJ Copland John A JA Bible Keith C KC
Science translational medicine 20130101 166
Anaplastic thyroid cancer (ATC) has perhaps the worst prognosis of any cancer, with a median survival of only about 5 months regardless of stage. Pazopanib monotherapy has promising clinical activity in differentiated thyroid cancers (generally attributed to vascular endothelial growth factor receptor inhibition), yet has less effective single-agent activity in ATC. We now report that combining pazopanib with microtubule inhibitors such as paclitaxel produced heightened and synergistic antitumor ...[more]