Chromatin modifications sequentially enhance ErbB2 expression in ErbB2-positive breast cancers.
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ABSTRACT:
SUBMITTER: Mungamuri SK
PROVIDER: S-EPMC3905738 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Chromatin modifications sequentially enhance ErbB2 expression in ErbB2-positive breast cancers.
Mungamuri Sathish Kumar SK Murk William W Grumolato Luca L Bernstein Emily E Aaronson Stuart A SA
Cell reports 20131010 2
ErbB2 gene amplification occurs in 20%-25% of breast cancers, and its therapeutic targeting has markedly improved survival of patients with breast cancer in the adjuvant setting. However, resistance to these therapies can develop. Because epigenetic mechanisms can importantly influence oncogene expression and be druggable as well, we investigated histone modifications that influence ErbB2 overexpression, independent of gene amplification. We demonstrate here that ErbB2-overexpressing breast carc ...[more]
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