Ontology highlight
ABSTRACT:
SUBMITTER: Morel E
PROVIDER: S-EPMC3905799 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Morel Etienne E Chamoun Zeina Z Lasiecka Zofia M ZM Chan Robin B RB Williamson Rebecca L RL Vetanovetz Christopher C Dall'Armi Claudia C Simoes Sabrina S Point Du Jour Kimberly S KS McCabe Brian D BD Small Scott A SA Di Paolo Gilbert G
Nature communications 20130101
Defects in endosomal sorting have been implicated in Alzheimer's disease. Endosomal traffic is largely controlled by phosphatidylinositol-3-phosphate, a phosphoinositide synthesized primarily by lipid kinase Vps34. Here we show that phosphatidylinositol-3-phosphate is selectively deficient in brain tissue from humans with Alzheimer's disease and Alzheimer's disease mouse models. Silencing Vps34 causes an enlargement of neuronal endosomes, enhances the amyloidogenic processing of amyloid precurso ...[more]