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Enantioselective N-heterocyclic carbene catalyzed annulation reactions with imidazolidinones.

ABSTRACT: Add acetic acid: A highly stereoselective N-heterocyclic carbene (NHC)-catalyzed formal [4+2] annulation between ?,?-unsaturated aldehydes and imidazolidinones for the synthesis of imidazoles has been developed. Acetic acid serves as a key additive to achieve high chemoselectivity for the formal [4+2]?annulation product.

SUBMITTER: McCusker EO

PROVIDER: S-EPMC3905989 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Enantioselective N-heterocyclic carbene catalyzed annulation reactions with imidazolidinones.

McCusker Elizabeth O'Bryan EO Scheidt Karl A KA

Angewandte Chemie (International ed. in English) 20131118 51

Add acetic acid: A highly stereoselective N-heterocyclic carbene (NHC)-catalyzed formal [4+2] annulation between α,β-unsaturated aldehydes and imidazolidinones for the synthesis of imidazoles has been developed. Acetic acid serves as a key additive to achieve high chemoselectivity for the formal [4+2] annulation product. ...[more]

PMID: 24249661

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