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Neuroendocrine control of Drosophila larval light preference.


ABSTRACT: Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors--the Bolwig's organ and the peripheral class IV dendritic arborization neurons--to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.

SUBMITTER: Yamanaka N 

PROVIDER: S-EPMC3906047 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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Neuroendocrine control of Drosophila larval light preference.

Yamanaka Naoki N   Romero Nuria M NM   Martin Francisco A FA   Rewitz Kim F KF   Sun Mu M   O'Connor Michael B MB   Léopold Pierre P  

Science (New York, N.Y.) 20130901 6150


Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors--the Bolwig's organ and the peripheral class IV dendritic arborization neurons--to regulate light avoidance. We found that PTTH c  ...[more]

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