Ontology highlight
ABSTRACT:
SUBMITTER: Chandrananda D
PROVIDER: S-EPMC3906086 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Chandrananda Dineika D Thorne Natalie P NP Ganesamoorthy Devika D Bruno Damien L DL Benjamini Yuval Y Speed Terence P TP Slater Howard R HR Bahlo Melanie M
PloS one 20140129 1
Pregnant women carry a mixture of cell-free DNA fragments from self and fetus (non-self) in their circulation. In recent years multiple independent studies have demonstrated the ability to detect fetal trisomies such as trisomy 21, the cause of Down syndrome, by Next-Generation Sequencing of maternal plasma. The current clinical tests based on this approach show very high sensitivity and specificity, although as yet they have not become the standard diagnostic test. Here we describe improvements ...[more]