Determining the validity of hospital laboratory reference intervals for healthy young adults participating in early clinical trials of candidate vaccines.
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ABSTRACT:
SUBMITTER: Rowland R
PROVIDER: S-EPMC3906276 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
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Determining the validity of hospital laboratory reference intervals for healthy young adults participating in early clinical trials of candidate vaccines.
Rowland Rosalind R O'Hara Geraldine A GA Hamill Matthew M Poulton Ian D ID Donaldson Hannah H Dinsmore Laura L James Timothy T Barnes Eleanor E Klenerman Paul P Gilbert Sarah C SC Hill Adrian V S AV Shine Brian B McShane Helen H
Human vaccines & immunotherapeutics 20130603 8
This was a retrospective study to determine the validity of institutional reference intervals for interpreting biochemistry and hematology results in healthy adults in the context of clinical trials of preventive vaccines. An example population of 974 healthy adults participating in clinical trials at the Jenner Institute, Oxford, UK, between 1999 and 2009 was studied. Methods for calculating the central 95% ranges and determining the coefficients of within person variation were demonstrated. Re ...[more]
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