Ontology highlight
ABSTRACT:
SUBMITTER: Christen M
PROVIDER: S-EPMC3906730 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Christen Matthias M Kulasekara Hemantha D HD Christen Beat B Kulasekara Bridget R BR Hoffman Lucas R LR Miller Samuel I SI
Science (New York, N.Y.) 20100601 5983
The bacterial second messenger cyclic diguanosine monophosphate (c-di-GMP) regulates cellular motility and the synthesis of organelles and molecules that promote adhesion to a variety of biological and nonbiological surfaces. These properties likely require tight spatial and temporal regulation of c-di-GMP concentration. We have developed genetically encoded fluorescence resonance energy transfer (FRET)-based biosensors to monitor c-di-GMP concentrations within single bacterial cells by microsco ...[more]