Ontology highlight
ABSTRACT:
SUBMITTER: McKibbin PL
PROVIDER: S-EPMC3906845 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
McKibbin Paige L PL Fleming Aaron M AM Towheed Mohammad Atif MA Van Houten Bennett B Burrows Cynthia J CJ David Sheila S SS
Journal of the American Chemical Society 20130905 37
An important feature of the common DNA oxidation product 8-oxo-7,8-dihydroguanine (OG) is its susceptibility to further oxidation that produces guanidinohydantoin (Gh) and spiroiminodihydantoin (Sp) lesions. In the presence of amines, G or OG oxidation produces hydantoin amine adducts. Such adducts may form in cells via interception of oxidized intermediates by protein-derived nucleophiles or naturally occurring amines that are tightly associated with DNA. Gh and Sp are known to be substrates fo ...[more]