Ontology highlight
ABSTRACT:
SUBMITTER: Ha SW
PROVIDER: S-EPMC3906847 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Ha Seung-Wook SW Ju Donghong D Xie Youming Y
Biochemical and biophysical research communications 20120213 2
The number of proteasomal substrates that are degraded without prior ubiquitylation continues to grow. However, it remains poorly understood how the proteasome recognizes substrates lacking a ubiquitin (Ub) signal. Here we demonstrated that the Ub-independent degradation of Rpn4 requires the 19S regulatory particle (RP). The Ub-independent degron of Rpn4 was mapped to an N-terminal region including the first 80 residues. Inspection of its amino acid sequence revealed that the Ub-independent degr ...[more]