Ontology highlight
ABSTRACT:
SUBMITTER: Feuermann Y
PROVIDER: S-EPMC3907398 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Feuermann Yonatan Y Kang Keunsoo K Shamay Avi A Robinson Gertraud W GW Hennighausen Lothar L
PloS one 20140130 1
Development of mammary alveolar epithelium during pregnancy is controlled by prolactin, through the transcription factors STAT5A/B that activate specific sets of target genes. Here we asked whether some of STAT5's functions are mediated by microRNAs. The miR-21 promoter sequence contains a bona-fide STAT5 binding site and miR-21 levels increased in HC11 mammary cells upon prolactin treatment. In vivo miR-21 was abundantly expressed in mammary epithelium at day 6 of pregnancy. Analysis of mice la ...[more]