Ontology highlight
ABSTRACT:
SUBMITTER: Megison ML
PROVIDER: S-EPMC3907427 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Megison Michael L ML Gillory Lauren A LA Stewart Jerry E JE Nabers Hugh C HC Mroczek-Musulman Elizabeth E Waters Alicia M AM Coleman Jennifer M JM Kelly Virginia V Markert James M JM Gillespie G Yancey GY Friedman Gregory K GK Beierle Elizabeth A EA
PloS one 20140130 1
Recently, investigators showed that mice with syngeneic murine gliomas that were treated with a neuroattenuated oncolytic herpes simplex virus-1 (oHSV), M002, had a significant increase in survival. M002 has deletions in both copies of the γ134.5 gene, enabling replication in tumor cells but precluding infection of normal cells. Previous studies have shown antitumor effects of other oHSV against a number of adult tumors including hepatocellular carcinoma and renal cell carcinoma. The purpose of ...[more]