Ontology highlight
ABSTRACT:
SUBMITTER: Chen DY
PROVIDER: S-EPMC3908455 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Chen Dillon Y DY Stern Sarah A SA Garcia-Osta Ana A Saunier-Rebori Bernadette B Pollonini Gabriella G Bambah-Mukku Dhananjay D Blitzer Robert D RD Alberini Cristina M CM
Nature 20110101 7331
We report that, in the rat, administering insulin-like growth factor II (IGF-II, also known as IGF2) significantly enhances memory retention and prevents forgetting. Inhibitory avoidance learning leads to an increase in hippocampal expression of IGF-II, which requires the transcription factor CCAAT enhancer binding protein β and is essential for memory consolidation. Furthermore, injections of recombinant IGF-II into the hippocampus after either training or memory retrieval significantly enhance ...[more]