Ontology highlight
ABSTRACT:
SUBMITTER: Kunkel GT
PROVIDER: S-EPMC3908769 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Nature reviews. Drug discovery 20130819 9
The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has been implicated in disorders such as cancer and inflammatory diseases. This Review discusses the ways in which S1P might be therapeutically targeted - for example, via the development of chemical inhibitors that target the generation, transport and degradation of S1P and via the development of specific S1P recepto ...[more]