Statin use is associated with reduced risk of haematological malignancies: evidence from a meta-analysis.

ABSTRACT:

Background

Several observational studies have shown that statin use may modify the risk of haematological malignancies. To quantify the association between statin use and risk for haematological malignancies, we performed a detailed meta-analysis of published studies regarding this subject.

Methods

We conducted a systematic search of multiple databases including PubMed, Embase, and Cochrane Library Central database up to July 2013. Fixed-effect and random-effect models were used to estimate summary relative risks (RR) and the corresponding 95% confidence intervals (CIs). Potential sources of heterogeneity were detected by meta-regression. Subgroup analyses and sensitivity analysis were also performed.

Results

A total of 20 eligible studies (ten case-control studies, f

SUBMITTER: Yi X 

PROVIDER: S-EPMC3909054 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature