Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus.
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ABSTRACT:
SUBMITTER: Pavlou S
PROVIDER: S-EPMC3909122 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus.
Pavlou Sofia S Astell Katy K Kasioulis Ioannis I Gakovic Milica M Baldock Richard R van Heyningen Veronica V Coutinho Pedro P
PloS one 20140131 1
The zebrafish epithalamus is part of the diencephalon and encompasses three major components: the pineal, the parapineal and the habenular nuclei. Using sox2 knockdown, we show here that this key transcriptional regulator has pleiotropic effects during the development of these structures. Sox2 negatively regulates pineal neurogenesis. Also, Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling. Th ...[more]
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