Ontology highlight
ABSTRACT:
SUBMITTER: An D
PROVIDER: S-EPMC3909465 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
An Dingding D Oh Sungwhan F SF Olszak Torsten T Neves Joana F JF Avci Fikri Y FY Erturk-Hasdemir Deniz D Lu Xi X Zeissig Sebastian S Blumberg Richard S RS Kasper Dennis L DL
Cell 20140101 1-2
Coevolution of beneficial microorganisms with the mammalian intestine fundamentally shapes mammalian physiology. Here, we report that the intestinal microbe Bacteroides fragilis modifies the homeostasis of host invariant natural killer T (iNKT) cells by supplementing the host's endogenous lipid antigen milieu with unique inhibitory sphingolipids. The process occurs early in life and effectively impedes iNKT cell proliferation during neonatal development. Consequently, total colonic iNKT cell num ...[more]