Ontology highlight
ABSTRACT:
SUBMITTER: Witt H
PROVIDER: S-EPMC3909499 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Nature genetics 20130818 10
Chronic pancreatitis is an inflammatory disorder of the pancreas. We analyzed CPA1, encoding carboxypeptidase A1, in subjects with nonalcoholic chronic pancreatitis (cases) and controls in a German discovery set and three replication sets. Functionally impaired variants were present in 29/944 (3.1%) German cases and 5/3,938 (0.1%) controls (odds ratio (OR) = 24.9, P = 1.5 × 10(-16)). The association was strongest in subjects aged ≤ 10 years (9.7%; OR = 84.0, P = 4.1 × 10(-24)). In the replicatio ...[more]