Ontology highlight
ABSTRACT:
SUBMITTER: D'Urso A
PROVIDER: S-EPMC3909744 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
D'Urso Alessandro A Choi Jung Kyu JK Shabbir-Hussain Murtaza M Ngwa Fidelis N FN Lambousis Maria I MI Purrello Roberto R Balaz Milan M
Biochemical and biophysical research communications 20100527 2
The left-handed Z-DNA form of the short unmodified alternating guanine-cytosine oligonucleotides, 5'-(dGdC)(24) and 5'-(dGdC)(18), was selectively detected under physiological ionic strength and pH conditions using the anionic nickel(II) porphyrin, NiTPPS. No spectroscopic signal was observed for NiTPPS with any right-handed oligonucleotides under identical conditions. The 48mer 5'-(dGdC)(24) Z-form was detected at concentrations as low as 100nM. The binding of NiTPPS to the B- and Z-oligonucleo ...[more]