Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC3910015 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Li L L Gardner I I Rose R R Jamei M M
CPT: pharmacometrics & systems pharmacology 20140129
Shedding of a pharmacological target from cells, giving rise to a soluble target that can also bind therapeutic proteins, is a common phenomenon. In this study, a minimal physiologically based pharmacokinetic model was used to simulate the pharmacokinetics of trastuzumab and the simultaneous binding of the compound to soluble (in blood and tissue interstitial space) and membrane-bound (in the tissue interstitial space) forms of human epidermal growth factor receptor 2 (HER2). The parameter value ...[more]