SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer.
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ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC3910168 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer.
Li Lianjie L Shen Chuan C Nakamura Eijiro E Ando Kiyohiro K Signoretti Sabina S Beroukhim Rameen R Cowley Glenn S GS Lizotte Patrick P Liberzon Ella E Bair Steven S Root David E DE Tamayo Pablo P Tsherniak Aviad A Cheng Su-Chun SC Tabak Barbara B Jacobsen Anders A Hakimi A Ari AA Schultz Nikolaus N Ciriello Giovanni G Sander Chris C Hsieh James J JJ Kaelin William G WG
Cancer cell 20131201 6
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer and is often linked to loss of chromosome 3p, which harbors the VHL tumor suppressor gene, loss of chromosome 14q, which includes HIF1A, and gain of chromosome 5q. The relevant target(s) on chromosome 5q is not known. Here, we show that 5q amplification leads to overexpression of the SQSTM1 oncogene in ccRCC lines and tumors. Overexpression of SQSTM1 in ccRCC lines promoted resistance to redox stress and increased s ...[more]
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