Ontology highlight
ABSTRACT:
SUBMITTER: Suarez S
PROVIDER: S-EPMC3910395 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Suarez Sophia S Grover Gregory N GN Braden Rebecca L RL Christman Karen L KL Almutairi Adah A
Biomacromolecules 20131016 11
The leading cause of death in the United States is cardiovascular disease. The majority of these cases result from heart failure post-myocardial infarction (MI). We present data providing evidence for use of acetalated dextran (AcDex) microparticles as a delivery vehicle for therapeutics to the heart post-MI. We harnessed the tunable degradation and acid-sensitivity of AcDex in the design of microparticles for intramyocardial injection. The particles released a model protein, myoglobin, and a se ...[more]