Synthesis of Cyclic α-Aminophosphonates through Copper Catalyzed Enamine Activation.

ABSTRACT: A copper-catalyzed tandem cyclization triggered addition strategy that relies on electrophilic enamine activation has been used to synthesize various cyclic α-aminophosphonates derivatives in good to excellent yields. Both five and six membered rings can be generated under mild conditions with high regioselectivity. A mechanism based on copper catalyzed enamine activation is proposed.

SUBMITTER: Han J 

PROVIDER: S-EPMC3910425 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature