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Synthesis of Cyclic ?-Aminophosphonates through Copper Catalyzed Enamine Activation.

ABSTRACT: A copper-catalyzed tandem cyclization triggered addition strategy that relies on electrophilic enamine activation has been used to synthesize various cyclic ?-aminophosphonates derivatives in good to excellent yields. Both five and six membered rings can be generated under mild conditions with high regioselectivity. A mechanism based on copper catalyzed enamine activation is proposed.

SUBMITTER: Han J

PROVIDER: S-EPMC3910425 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Synthesis of Cyclic α-Aminophosphonates through Copper Catalyzed Enamine Activation.

Han Junbin J Paton Robert S RS Xu Bo B Hammond Gerald B GB

Synthesis 20130201 4

A copper-catalyzed tandem cyclization triggered addition strategy that relies on electrophilic enamine activation has been used to synthesize various cyclic α-aminophosphonates derivatives in good to excellent yields. Both five and six membered rings can be generated under mild conditions with high regioselectivity. A mechanism based on copper catalyzed enamine activation is proposed. ...[more]

PMID: 24501432

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