Novel codon insert in HIV type 1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy.
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ABSTRACT:
SUBMITTER: Chaillon A
PROVIDER: S-EPMC3910474 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
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Novel codon insert in HIV type 1 clade B reverse transcriptase associated with low-level viremia during antiretroviral therapy.
Chaillon Antoine A Gianella Sara S Vazquez Homero H Ignacio Caroline C Zweig Adam C AC Richman Douglas D DD Smith Davey M DM
AIDS research and human retroviruses 20131005 2
We investigated the pol genotype in two phylogenetically and epidemiologically linked partners, who were both experiencing persistent low-level viremia during antiretroviral therapy. In one partner we identified a new residue insertion between codon 248 and 249 of the HIV-1 RNA reverse transcriptase (RT) coding region (HXB2 numbering). We then investigated the potential impact of identified mutations in RT and antiretroviral binding affinity using a novel computational approach. ...[more]
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