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Coronary heart disease alters intercellular communication by modifying microparticle-mediated microRNA transport.

ABSTRACT: Coronary heart disease (CHD) is characterized by abnormal intercellular communication and circulating microRNAs (miRNAs) are likely involved in this process. Here, we show that CHD was associated with changes in the transport of circulating miRNA, particularly decreased miRNA enrichment in microparticles (MPs). Additionally, MPs from CHD patients were less efficient at transferring miRNA to cultured HUVECs, which correlated with their diminished capacity to bind developmental endothelial locus-1 (Del-1). In summary, CHD was associated with distinct changes in circulating miRNA transport and these changes may contribute to the abnormal intercellular communication that underlies CHD initiation and progression.

SUBMITTER: Finn NA

PROVIDER: S-EPMC3910498 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Coronary heart disease alters intercellular communication by modifying microparticle-mediated microRNA transport.

Finn Nnenna A NA Eapen Danny D Manocha Pankaj P Al Kassem Hatem H Lassegue Bernard B Ghasemzadeh Nima N Quyyumi Arshed A Searles Charles D CD

FEBS letters 20130913 21

Coronary heart disease (CHD) is characterized by abnormal intercellular communication and circulating microRNAs (miRNAs) are likely involved in this process. Here, we show that CHD was associated with changes in the transport of circulating miRNA, particularly decreased miRNA enrichment in microparticles (MPs). Additionally, MPs from CHD patients were less efficient at transferring miRNA to cultured HUVECs, which correlated with their diminished capacity to bind developmental endothelial locus-1 ...[more]

PMID: 24042051

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