Ontology highlight
ABSTRACT:
SUBMITTER: Stommel JM
PROVIDER: S-EPMC391059 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Stommel Jayne M JM Wahl Geoffrey M GM
The EMBO journal 20040318 7
p53 activation prevents the proliferation of genetically unstable cells. Conversely, p53 antagonism by its transcriptional target, the E3 ubiquitin ligase MDM2, is critical for the viability of unstressed, cycling cells. We demonstrate that MDM2 induces the degradation of p53 in both the nucleus and the cytoplasm. As p53 and MDM2 accumulate in the nuclei of stressed cells, we investigated mechanisms enabling p53 activation despite the high MDM2 levels generated during a DNA-damage response. We s ...[more]