Ontology highlight
ABSTRACT:
SUBMITTER: Goldner T
PROVIDER: S-EPMC3910730 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Goldner Thomas T Hempel Christine C Ruebsamen-Schaeff Helga H Zimmermann Holger H Lischka Peter P
Antimicrobial agents and chemotherapy 20131104 1
Letermovir is a novel antiviral compound currently in clinical development for the prevention of human cytomegalovirus (HCMV) infections. In contrast to all currently approved anti-HCMV drugs that target the viral DNA polymerase, letermovir acts via a distinct mode of action involving the viral terminase subunit pUL56. To extend our understanding of potential letermovir resistance mechanisms, we used marker transfer to characterize mutations identified in letermovir-resistant HCMV variants that ...[more]